Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Pediatr. 2014 Apr 29;2:36. doi: 10.3389/fped.2014.00036. eCollection 2014.

New Insights into Congenital Diaphragmatic Hernia - A Surgeon's Introduction to CDH Animal Models.

Author information

1
Division of Pediatric General and Thoracic Surgery, Department of Surgery, The Hospital for Sick Children, University of Toronto , Toronto, ON , Canada.

Abstract

In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of many important genetic, epigenetic, and other molecular contributors to this condition. In this review, the most commonly used and newly devised animal models of CDH are presented to familiarize the reader with the latest innovations in the basic sciences.

KEYWORDS:

congenital diaphragmatic hernia; fetal lamb; fetal surgery; fetal tracheal occlusion; genetic models; pulmonary hypoplasia; teratogen

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center