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Front Pediatr. 2014 Apr 29;2:36. doi: 10.3389/fped.2014.00036. eCollection 2014.

New Insights into Congenital Diaphragmatic Hernia - A Surgeon's Introduction to CDH Animal Models.

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Division of Pediatric General and Thoracic Surgery, Department of Surgery, The Hospital for Sick Children, University of Toronto , Toronto, ON , Canada.


In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of many important genetic, epigenetic, and other molecular contributors to this condition. In this review, the most commonly used and newly devised animal models of CDH are presented to familiarize the reader with the latest innovations in the basic sciences.


congenital diaphragmatic hernia; fetal lamb; fetal surgery; fetal tracheal occlusion; genetic models; pulmonary hypoplasia; teratogen

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