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Mediators Inflamm. 2014;2014:834831. doi: 10.1155/2014/834831. Epub 2014 Apr 8.

A polymorphism of ORAI1 rs7135617, is associated with susceptibility to rheumatoid arthritis.

Author information

1
College of Medicine, Kaohsiung Medical University, and Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 83301, Taiwan.
2
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
3
Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan ; Chang Gung University College of Medicine, Taoyuan 33302, Taiwan.
4
Division of Nephrology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan.
5
Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan.
6
Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taipei Medical University-Wan Fang Hospital, Taipei 11696, Taiwan ; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11696, Taiwan.
7
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, Taipei 11696, Taiwan.
8
Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan ; Department of Pharmacy, Taipei Medical University-Wan Fang Hospital, Taipei 11696, Taiwan ; Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan ; Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.

Abstract

Rheumatoid arthritis (RA), a chronic inflammatory disease usually occurring in synovial tissues and joints, is highly associated with genetic and environmental factors. ORAI1, a gene related to cellular immune system, has been shown to be involved in the pathogenesis of chronic inflammatory diseases and immune diseases. To identify whether ORAI1 gene contributes to RA susceptibility, we enrolled 400 patients with RA and 621 healthy individuals for a case-control genetic association study. Five tagging single nucleotides polymorphisms (tSPNs) within ORAI1 gene were selected for genotyping. An SNP, rs7135617, showed a significant correlation with the risk of RA. Our results indicated that genetic polymorphism of ORAI1 gene is involved in the susceptibility of RA in a Taiwanese population.

PMID:
24808640
PMCID:
PMC3997980
DOI:
10.1155/2014/834831
[Indexed for MEDLINE]
Free PMC Article
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