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Cell Metab. 2014 May 6;19(5):735-6. doi: 10.1016/j.cmet.2014.04.010.

Obesity corrupts myelopoiesis.

Author information

1
Departments of Infectious Diseases and Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: peter.murray@stjude.org.

Abstract

Ongoing monocyte infiltration and subsequent macrophage seeding of adipose tissue is thought to be a key feature of obesity pathophysiology. Nagareddy et al. (2014) show that adipose cells locally activate IL-1β in macrophages in part through the alarmin S100A8/A9, which stimulates bone marrow myelopoiesis to perpetuate nonresolving inflammation.

PMID:
24807218
DOI:
10.1016/j.cmet.2014.04.010
[Indexed for MEDLINE]
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