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Int J Mol Sci. 2014 May 6;15(5):7865-82. doi: 10.3390/ijms15057865.

Biomarkers in Alzheimer's disease analysis by mass spectrometry-based proteomics.

Author information

1
School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China. liuyahui2049@163.com.
2
School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China. hqing@bit.edu.cn.
3
School of Life Science, Beijing Institute of Technology, No. 5 Zhongguancun South Street, Haidian District, Beijing 100081, China. deng@bit.edu.cn.

Abstract

Alzheimer's disease (AD) is a common chronic and destructive disease. The early diagnosis of AD is difficult, thus the need for clinically applicable biomarkers development is growing rapidly. There are many methods to biomarker discovery and identification. In this review, we aim to summarize Mass spectrometry (MS)-based proteomics studies on AD and discuss thoroughly the methods to identify candidate biomarkers in cerebrospinal fluid (CSF) and blood. This review will also discuss the potential research areas on biomarkers.

PMID:
24806343
PMCID:
PMC4057708
DOI:
10.3390/ijms15057865
[Indexed for MEDLINE]
Free PMC Article

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