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Int J Environ Res Public Health. 2014 May 6;11(5):4870-85. doi: 10.3390/ijerph110504870.

Hematological and biochemical data obtained in rural northern Uganda.

Author information

1
Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. nirian@biken.osaka-u.ac.jp.
2
Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda. ehntege@gmail.com.
3
Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda. bettymawagali@gmail.com.
4
Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda. yadoke@yahoo.com.
5
The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan. hshirai@mail.biken.or.jp.
6
The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan. napokoko@gmail.com.
7
Lira Medical Center, Lira, Uganda. chrisdoc23@yahoo.com.
8
Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda. bnkanoi@gmail.com.
9
The Research Foundation for Microbial Diseases of Osaka University, 2-9-41 Yahata-cho, Kanonji, Kagawa 768-0061, Japan. tkokada@mail.biken.or.jp.
10
Med Biotech Laboratories, P.O. Box 9364, Kampala, Uganda. tgegwang@gmail.com.
11
Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0871, Japan. horii@biken.osaka-u.ac.jp.

Abstract

Reference intervals for common hematological and clinical chemistry parameters constitute an important basis for health care. Moreover, with increasing priority in drug and vaccine development for infectious diseases in Africa, the first priority is the safety evaluation and tolerability of the candidate interventions in healthy populations. To accurately assess health status and address adverse events, clinical reference intervals in the target population are necessary. We report on hematological and biochemical indices from healthy volunteers who participated in a clinical trial in Lira, northern Uganda. Median and nonparametric 95% percentiles on five hematology and 15 biochemistry analytes are shown. Although most hematological analytes conformed to reported reference intervals and trends in Africa, literature review from different African countries highlight the need for a region-specific children reference interval that can be appropriate for the population.

PMID:
24806194
PMCID:
PMC4053919
DOI:
10.3390/ijerph110504870
[Indexed for MEDLINE]
Free PMC Article

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