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Nature. 2014 May 15;509(7500):331-6. doi: 10.1038/nature13240. Epub 2014 May 4.

Space-time wiring specificity supports direction selectivity in the retina.

Author information

1
1] Brain & Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2].
2
Electrical Engineering and Computer Science Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
3
Brain & Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
4
1] Brain & Cognitive Sciences Department, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA [2] 601 N 42nd Street, Seattle, Washington 98103, USA (M.R.); Princeton Neuroscience Institute and Computer Science Deptartment, Princeton, New Jersey 08544, USA (H.S.S.); Gatsby Computational Neuroscience Unit, London WC1N 3AR, UK (S.C.T.).
5
Qualcomm Research, 5775 Morehouse Drive, San Diego, California 92121, USA.
6
Max-Planck Institute for Medical Research, D-69120 Heidelberg, Germany.

Abstract

How does the mammalian retina detect motion? This classic problem in visual neuroscience has remained unsolved for 50 years. In search of clues, here we reconstruct Off-type starburst amacrine cells (SACs) and bipolar cells (BCs) in serial electron microscopic images with help from EyeWire, an online community of 'citizen neuroscientists'. On the basis of quantitative analyses of contact area and branch depth in the retina, we find evidence that one BC type prefers to wire with a SAC dendrite near the SAC soma, whereas another BC type prefers to wire far from the soma. The near type is known to lag the far type in time of visual response. A mathematical model shows how such 'space-time wiring specificity' could endow SAC dendrites with receptive fields that are oriented in space-time and therefore respond selectively to stimuli that move in the outward direction from the soma.

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PMID:
24805243
PMCID:
PMC4074887
DOI:
10.1038/nature13240
[Indexed for MEDLINE]
Free PMC Article
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