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Nature. 1989 Dec 7;342(6250):643-8.

Cloning by functional expression of a member of the glutamate receptor family.

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1
Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037.

Abstract

We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.

PMID:
2480522
DOI:
10.1038/342643a0
[Indexed for MEDLINE]
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