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J Int AIDS Soc. 2014 May 6;17:18617. doi: 10.7448/IAS.17.1.18617. eCollection 2014.

Comparing the efficacy of efavirenz and boosted lopinavir using viremia copy-years.

Author information

1
British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, BC, Canada; Division of AIDS, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; vlima@cfenet.ubc.ca.
2
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
3
Chinese Center for Disease Control and Prevention, Beijing, China.
4
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; CIHR Canadian HIV Trials Network, Vancouver, BC, Canada.
5
British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, BC, Canada; Division of AIDS, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Abstract

INTRODUCTION:

HIV-1 plasma viral load during treatment can be highly variable. Thus, there is the need to find a measure of cumulative viremia that can be used to assess both the short- and long-term efficacy of highly active antiretroviral therapy (HAART). Here, we validate a measure of cumulative viremia to evaluate HAART efficacy.

METHODS:

We accessed HAART efficacy using data from a randomized clinical trial conducted in Mexico. We compared the proportion of individuals achieving a viral load <50 and <400 copies/mL at week 48, against the cumulative plasma viral load, estimated as the area under the plasma viral load curve (AUVLC). High AUVLC indicates high cumulative viremia.

RESULTS AND DISCUSSION:

There was a strong and significant association between the proportion of individuals achieving a viral load <50 and <400 copies/mL at week 48, with individuals suppressed having significant lower cumulative viremia. The median area was 7513 (25th-75th percentile [Q1-Q3] 6634-8180) if viral load <50 copies/mL and 7679 (Q1-Q3 6899-9373) if viral load ≥50 copies/mL (p-value 0.0284). When the analysis was stratified by study arm, individuals on efavirenz had lower cumulative viremia than those on boosted lopinavir.

CONCLUSIONS:

Our findings suggest that cumulative viremia should be explored further as a tool to simultaneously evaluate the individual and public health efficacy of HAART. This is particularly relevant to the implementation and evaluation of the Treatment 2.0 strategy recently proposed by UNAIDS and the WHO, as a means to maximize the individual and public health benefit of HAART.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00162643.

KEYWORDS:

HIV-1 plasma viral load; antiretroviral therapy; area under the curve; boosted lopinavir; clinical trial; cumulative viremia; efavirenz; efficacy

PMID:
24805184
PMCID:
PMC4013478
[Indexed for MEDLINE]
Free PMC Article

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