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Nat Rev Genet. 2014 Jun;15(6):409-21. doi: 10.1038/nrg3723. Epub 2014 May 8.

Routes for breaching and protecting genetic privacy.

Author information

1
Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, Massachusetts 02142, USA.
2
Department of Computer Science, Princeton University, 35 Olden Street, Princeton, New Jersey 08540, USA.

Erratum in

  • Nat Rev Genet. 2014 Aug;15(8):570.

Abstract

We are entering an era of ubiquitous genetic information for research, clinical care and personal curiosity. Sharing these data sets is vital for progress in biomedical research. However, a growing concern is the ability to protect the genetic privacy of the data originators. Here, we present an overview of genetic privacy breaching strategies. We outline the principles of each technique, indicate the underlying assumptions, and assess their technological complexity and maturation. We then review potential mitigation methods for privacy-preserving dissemination of sensitive data and highlight different cases that are relevant to genetic applications.

PMID:
24805122
PMCID:
PMC4151119
DOI:
10.1038/nrg3723
[Indexed for MEDLINE]
Free PMC Article

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