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J Leukoc Biol. 2014 Nov;96(5):739-43. doi: 10.1189/jlb.1MR0114-068R. Epub 2014 May 7.

Serum amyloid P: a systemic regulator of the innate immune response.

Author information

1
Department of Biology, Texas A&M University, College Station, Texas, USA ncox@bio.tamu.edu.
2
Department of Biology, Texas A&M University, College Station, Texas, USA.

Abstract

The pentraxin SAP reduces neutrophil adhesion to ECM proteins, inhibits the differentiation of monocytes into fibrocytes, attenuates profibrotic macrophages, activates the complement pathway, and promotes phagocytosis of cell debris. Together, these effects of SAP regulate key aspects of inflammation and set a threshold for immune cell activation. Here, we present a review of SAP biology with an emphasis on SAP receptor interactions and how the effect of SAP on monocytes and macrophages has been explored to develop this protein as a therapeutic for renal and lung injuries. We also discuss how there remain many unanswered questions about the role of SAP in innate immunity.

KEYWORDS:

Fcγ receptors; fibrocyte differentiation; fibrosis; macrophage polarization; neutrophil adhesion; phagocytosis

PMID:
24804675
DOI:
10.1189/jlb.1MR0114-068R
[Indexed for MEDLINE]

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