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Food Sci Nutr. 2013 Mar;1(2):141-9. doi: 10.1002/fsn3.21. Epub 2013 Jan 7.

Noni juice reduces lipid peroxidation-derived DNA adducts in heavy smokers.

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Department of Pathology, University of Illinois College of Medicine at Rockford 1601 Parkview Avenue, Rockford, Illinois.
Research and Development, Morinda, Inc. 737 East 1180 South, American Fork, Utah.


Food plants provide important phytochemicals which help improve or maintain health through various biological activities, including antioxidant effects. Cigarette smoke-induced oxidative stress leads to the formation of lipid hydroperoxides (LOOHs) and their decomposition product malondialdehyde (MDA), both of which cause oxidative damage to DNA. Two hundred forty-five heavy cigarette smokers completed a randomized, double-blind, placebo-controlled clinical trial designed to investigate the effect of noni juice on LOOH- and MDA-DNA adducts in peripheral blood lymphocytes (PBLs). Volunteers drank noni juice or a fruit juice placebo every day for 1 month. DNA adducts were measured by (32)P postlabeling analysis. Drinking 29.5-118 mL of noni juice significantly reduced adducts by 44.6-57.4%. The placebo, which was devoid of iridoid glycosides, did not significantly influence LOOH- and MDA-DNA adduct levels in current smokers. Noni juice was able to mitigate oxidative damage of DNA in current heavy smokers, an activity associated with the presence of iridoids.


Antioxidant; DNA adducts; Morinda citrifolia; noni

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