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Oxid Med Cell Longev. 2014;2014:897296. doi: 10.1155/2014/897296. Epub 2014 Apr 3.

Psoralea corylifolia L. seed extract ameliorates streptozotocin-induced diabetes in mice by inhibition of oxidative stress.

Author information

1
College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Republic of Korea ; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea.
2
Nanomol Inc. and Regen Phoenix R&D Institute, Incheon 406-840, Republic of Korea.
3
College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Republic of Korea.
4
KM-Based Herbal Drug Research Group, Korea Institute of Oriental Medicine, Daejeon 305-811, Republic of Korea.
5
College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Republic of Korea ; Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea ; Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Republic of Korea.

Abstract

Pancreatic beta-cell death is known to be the cause of deficient insulin production in diabetes mellitus. Oxidative stress is one of the major causes of beta-cell death. In this study, we investigated the effects of Psoralea corylifolia L. seed (PCS) extract on beta-cell death. Oral administration of PCS extract resulted in a significant improvement of hyperglycemia in streptozotocin-induced diabetic mice. PCS extract treatment improved glucose tolerance and increased serum insulin levels. To study the mechanisms involved, we investigated the effects of PCS extract on H2O2-induced apoptosis in INS-1 cells. Treatment with PCS extract inhibited cell death. PCS extract treatment decreased reactive oxygen species level and activated antioxidative enzymes. Among the major components of PCS extract, psoralen and isopsoralen (coumarins), but not bakuchiol, showed preventive effects against H2O2-induced beta-cell death. These findings indicate that PCS extract may be a potential pharmacological agent to protect against pancreatic beta-cell damage caused by oxidative stress associated with diabetes.

PMID:
24803987
PMCID:
PMC3997102
DOI:
10.1155/2014/897296
[Indexed for MEDLINE]
Free PMC Article

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