Format

Send to

Choose Destination
J Phys Chem C Nanomater Interfaces. 2014 Feb 20;118(7):3708-3715. Epub 2014 Jan 14.

Development of Hybrid Silver-Coated Gold Nanostars for Nonaggregated Surface-Enhanced Raman Scattering.

Author information

1
Fitzpatrick Institute for Photonics, Department of Biomedical Engineering, and Department of Chemistry, Duke University , Durham, North Carolina 27708, United States.

Abstract

In the ongoing search for ever-brighter surface-enhanced Raman scattering (SERS) nanoprobes, gold nanostars (AuNSs) have emerged as one of the best geometries for producing SERS in a nonaggregated state. Despite their high enhancement factor, optical extinction from plasmon-matched nanoparticles can greatly attenuate the overall SERS intensity. Herein, we report the development of a new hybrid bimetallic NS-based platform that exhibits superior resonant SERS (SERRS) properties. In this new nanoplatform, coating AuNSs with a subtotal layer of silver (AuNS@Ag) can further increase their SERRS brightness by an order of magnitude when being interrogated by an off-resonant excitation source. Silica-encapsulated AuNS@Ag nanoprobes were injected intradermally into a rat pelt, where SERRS was readily detected with higher signal-to-noise than nanoprobes prepared from AuNS. Moreover, these off-resonance AuNS@Ag nanoprobes did not cause any gross photothermal damage to tissue, which was observed with the plasmon-matched AuNSs. This novel SERRS-active hybrid nanoprobe exhibits high SERRS brightness and offers promising properties for future applications in sensing and molecular imaging.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center