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Adv Urol. 2014;2014:957013. doi: 10.1155/2014/957013. Epub 2014 Apr 3.

Structured Self-Rated Response to Iontophoresis with Verapamil and Dexamethasone in Peyronie's Disease.

Author information

1
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK.
2
Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S10 2JF, UK ; Sheffield Health and Social Care NHS Foundation Trust, Sheffield S11 9BF, UK.
3
Sheffield Health and Social Care NHS Foundation Trust, Sheffield S11 9BF, UK.

Abstract

INTRODUCTION:

New therapies evolve for the treatment of Peyronie's disease (PD) including the application of dexamethasone and verapamil using Electro Motive Drug Administration (EMDA).

PATIENTS AND METHODS:

Patients with PD were routinely offered Potaba, Vitamin E, tamoxifen or colchicine for 6 to 18 months and for those with no improvement, 18 applications of dexamethasone and verapamil using EMDA occurred over a 6 week period. All 30 patients receiving EMDA therapy completed a questionnaire before and after treatment. The data was collected from December 2004 to November 2009 and analysed to evaluate the effectiveness of the treatment.

RESULTS:

Median age of patients was 59 (range 39-71). Curvature was the most common presenting complaint (73.3%) followed by pain (23.3%), erectile dysfunction (13.3%), and lump (13.3%). 24/30 (80%) reported an improvement in symptoms after EMDA. 16 of the responders (66.7%) had a stable plaque for at least 6 months. The patients who complained of shortening of the penis (P = 0.003) or lowered sexual desire (P = 0.024) expressed subsequently significant response to treatment. There was statistically significant (P = 0.019) improvement of penile deviation reported by responding men.

CONCLUSION:

A significant proportion of patients who received EMDA reported decreased curvature following iontophoresis. No serious adverse reactions developed.

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