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J Food Sci Technol. 2014 May;51(5):908-14. doi: 10.1007/s13197-011-0568-9. Epub 2011 Oct 27.

Ameliorating activity of ginger (Zingiber officinale) extract against lead induced renal toxicity in male rats.

Author information

1
Department of Zoology, Sri Krishnadevaraya University, Anantapur, 515 003 Andhra Pradesh India.
2
Food and Drug Toxicology Research Centre, National Institute of Nutrition, Hyderabad, 500 604 Andhra Pradesh India.
3
Department of Biochemistry, Sri Venkateswara University, Tirupati, 517 502 Andhra Pradesh India.
4
Department of Pharmacology, Sri Krishnadevaraya University, Anantapur, 515 003 Andhra Pradesh India.

Abstract

Lead poisoning has been known to be associated with structural and functional abnormalities of multiple organ systems of human body. The aim of this investigation was to study the renal protective effects of ginger (Zingiber officinale) extract in lead induced toxicity rats. In this study renal glutathione (GSH) level, glutathione peroxidase (GPX), glutathione-s-transferase (GST), and catalase enzymes were measured in lead nitrate (300 mg/kg BW), and lead nitrate plus ginger extract (150 mg/kg BW) treated rat groups for 1 week and 3 weeks respectively. The glutathione level and GSH dependent antioxidant enzymes such as glutathione peroxidase, glutathione-s-transferase, and catalase significantly (P < 0.05) increased in ginger extract treated rat groups. In addition, histological studies showed lesser renal changes in lead plus ginger extract treated rat groups than that of lead alone treated rat groups. These results indicate that ginger extract alleviated lead toxic effects by enhancing the levels of glutathione, glutathione peroxidase, glutathione-s-transferase and catalase.

KEYWORDS:

Ginger (Zingiber officinale) extract; Glutathione (GSH); Glutathione dependent antioxidant enzymes; Lead toxicity; Rat kidney

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