Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Infect Dis. 2014 Aug 1;59(3):384-9. doi: 10.1093/cid/ciu325. Epub 2014 May 6.

Incidence and risk factors for the prozone phenomenon in serologic testing for syphilis in a large cohort.

Author information

1
Zhongshan Hospital, Medical College of Xiamen University Xiamen Zhongshan Hospital, Fujian Medical University Xiamen Zhongshan Hospital, Fujian University of Traditional Chinese Medicine, Xiamen.
2
Zhongshan Hospital, Medical College of Xiamen University Xiamen Zhongshan Hospital, Fujian University of Traditional Chinese Medicine, Xiamen.
3
Zhongshan Hospital, Medical College of Xiamen University.
4
Department of Chemistry and Biology, College of Science, National University of Defense and Technology, Changsha, China.
5
Department of Physiology and Neurobiology, University of Connecticut, Storrs.
6
Zhongshan Hospital, Medical College of Xiamen University Xiamen Zhongshan Hospital, Fujian University of Traditional Chinese Medicine, Xiamen ShenZhen Research Institute of Xiamen University, ShenZhen, China.

Abstract

BACKGROUND:

The prozone phenomenon is known to be associated with high antibody titers; other associations, such as host factors, have not been elucidated.

METHODS:

A retrospective analysis was conducted to evaluate the incidence of the prozone phenomenon of the syphilis rapid plasma reagin (RPR) test among 46 856 clinical samples, between June 2010 and June 2013. Logistic regression was used to analyze the risk factors of the prozone phenomenon.

RESULTS:

Our results showed that the incidence of the prozone phenomenon was low (0.83%) and could occur during any clinical phase, particularly during primary and secondary syphilis. Pregnancy and neurosyphilis were associated with the prozone phenomenon; sex, age, and whether the patient had been treated were not. The results also revealed that the prozone phenomenon not only occurred in patients with a high titer but also could occur in patients with a moderate/low titer. In fact, almost 31% of the patients with the prozone phenomenon had titers ≤1:16.

CONCLUSIONS:

The prozone phenomenon in the RPR test was associated with the phase of syphilis, pregnancy, and neurosyphilis as well as a range of RPR titers between 1:8 and 1:512. This latter finding is in contrast to previous reports that the prozone phenomenon is associated with very high RPR titers.

KEYWORDS:

prozone phenomenon; rapid plasma reagin; serologic test; syphilis

PMID:
24803377
DOI:
10.1093/cid/ciu325
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center