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Clin Infect Dis. 2014 Aug 15;59(4):545-8. doi: 10.1093/cid/ciu323. Epub 2014 May 6.

Molecular and virological evidence of viral activation from chromosomally integrated human herpesvirus 6A in a patient with X-linked severe combined immunodeficiency.

Author information

1
Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University Department of Pediatrics, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital.
2
Department of Virology, Tokyo Medical and Dental University.
3
Division of Molecular Genetics, Fujita Health University, Toyoake.
4
Department of Pediatrics, Juntendo University Urayasu Hospital.
5
Department of Pediatrics, Fujita Health University, Toyoake.
6
Department of Pathology.
7
Department of Virology I, National Institute of Infectious Diseases, Tokyo, Japan.
8
Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University.

Abstract

It has been unclear whether chromosomally integrated human herpesvirus 6 (ciHHV-6) can be activated with pathogenic effects on the human body. We present molecular and virological evidence of ciHHV-6A activation in a patient with X-linked severe combined immunodeficiency. These findings have significant implications for the management of patients with ciHHV-6.

KEYWORDS:

HHV-6; X-SCID; ciHHV-6; hemophagocytic syndrome; thrombotic microangiopathy

PMID:
24803376
DOI:
10.1093/cid/ciu323
[Indexed for MEDLINE]

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