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Expert Rev Respir Med. 2014 Jun;8(3):275-91. doi: 10.1586/17476348.2014.905914. Epub 2014 May 6.

Fluticasone propionate/formoterol fumarate in fixed-dose combination for the treatment of asthma.

Author information

1
Academic Primary Care, University of Aberdeen, Aberdeen, Scotland.

Abstract

A new combination inhaler containing fluticasone, a potent inhaled corticosteroid (ICS), and formoterol, a long-acting β-agonist (LABA) with rapid onset and sustained bronchodilator effect, has been approved for treatment of persistent asthma in patients ≥12 years of age requiring combination ICS-LABA therapy. The fluticasone/formoterol combination, delivered via pressurized metered-dose inhaler and available in three dose strengths, has demonstrated a good safety and tolerability profile in trials of up to 1 year. The efficacy of fluticasone/formoterol is greater than that of fluticasone or formoterol alone and noninferior to that of fluticasone/salmeterol and budesonide/formoterol in tightly controlled 8-12-week clinical trials. Advantages of the fluticasone/formoterol combination aerosol include rapid onset of bronchodilation, an attribute preferred by patients, and emission of a high fine-particle fraction that is consistent at different flow rates, which may aid consistency of delivery (given patient variability in inhalation maneuvers) and provide real-life benefits.

KEYWORDS:

anti-inflammatory; asthma; bronchodilator; fluticasone propionate; formoterol fumarate; inhaled corticosteroid; long-acting β-agonist

PMID:
24802285
DOI:
10.1586/17476348.2014.905914
[Indexed for MEDLINE]

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