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Dtsch Med Wochenschr. 2014 Jul;139(30):1523-34; quiz 1535-8. doi: 10.1055/s-0034-1370055. Epub 2014 May 6.

[Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options].

[Article in German]

Author information

1
Institut für Humangenetik, Universitätsklinikum Bonn.
2
Abteilung für Innere Medizin, Gemeinschaftskrankenhaus Bonn.
3
Klinik für Onkologie, Hämatologie und Palliativmedizin, Kreiskrankenhaus Waldbröl.
4
Medizinische Klinik 1, Universitätsklinikum Erlangen.
5
Medizinische Klinik II, HELIOS Klinikum Krefeld.

Abstract

In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell activation disease, as well as to counsel a personalized drug therapy. In the case of chronic multisystem polymorbidity systemic mast cell activation disease should be considered as a differential diagnosis at an early stage. In most cases, specific, little invasive investigations allow diagnosing the disease and, hence, an appropriate therapy can be initiated.

PMID:
24801454
DOI:
10.1055/s-0034-1370055
[Indexed for MEDLINE]

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