Format

Send to

Choose Destination
Curr Biol. 2014 May 5;24(9):R351-4. doi: 10.1016/j.cub.2014.03.032.

Post-translational modifications of tubulin.

Author information

1
Institut Curie, CNRS UMR3306, INSERM U1005, Centre Universitaire, Bâtiment 110, 91405 Orsay, France.
2
Institut Curie, CNRS UMR3306, INSERM U1005, Centre Universitaire, Bâtiment 110, 91405 Orsay, France. Electronic address: carsten.janke@curie.fr.

Abstract

Microtubules are the largest filamentous components of the eukaryotic cytoskeleton. In spite of their extraordinary level of structural conservation, microtubules fulfill a vast range of different functions in cells. How this functional diversity is achieved remains an open question; however, recent advances point towards post-translational modifications (PTMs) of tubulin as a potent mechanism to generate microtubule identities. As many microtubule functions have direct implications for development and homeostasis of organisms, understanding the molecular functions of tubulin PTMs could provide a more differentiated view on the role of microtubules in both normal and pathological aspects of organism development.

PMID:
24801181
DOI:
10.1016/j.cub.2014.03.032
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center