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Nutrition. 2014 Jun;30(6):628-35. doi: 10.1016/j.nut.2013.11.007. Epub 2013 Dec 1.

Cognitive and motor perturbations in elderly with longstanding diabetes mellitus.

Author information

1
Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina.
2
Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; Cátedra de Histología, Embriología y Genética, Universidad Nacional de La Rioja, La Rioja, Argentina; CONICET, Argentina.
3
CONICET, Argentina; Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina.
4
Department of Medicine, GVP Hospital and BioScience Research Centre, Campus of Gayatri Vidya Parishad College of Engineering, Visakhapatnam, India; UND Life Sciences, Federal Way, Washington, USA.
5
Biología Celular, Histología y Embriología, Facultad de Ciencias Médicas, INICSA (CONICET-Universidad Nacional de Córdoba), Córdoba, Argentina; CONICET, Argentina. Electronic address: Aeynard@gmail.com.

Abstract

Type 2 diabetes mellitus is a chronic disease characterized by insulin resistance; inflammation; oxidative stress; vascular damage; and dysfunction of glucose, protein, and lipid metabolisms. However, comparatively less attention has been paid to neurologic alterations seen in elderly individuals with type 2 diabetes. We review clinical, metabolic, and biochemical aspects of diabetic encephalopathy (DE) and propose that quality of dietary lipids is closely linked to DE. This implies that preventive nutritional interventions may be designed to improve DE.

KEYWORDS:

DE (Diabetic Encephalopathy); Diabetes mellitus; Dietary lipids; Insulin resistance; Oxidative stress

PMID:
24800665
DOI:
10.1016/j.nut.2013.11.007
[Indexed for MEDLINE]

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