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Oncoimmunology. 2014 Jan 1;3(1):e27456. Epub 2014 Jan 3.

The immune landscape of human tumors: Implications for cancer immunotherapy.

Author information

1
INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France.
2
INSERM U872; Laboratory of Integrative Cancer Immunology; Paris, France ; Université Paris Descartes; Paris, France ; Cordeliers Research Centre; Université Pierre et Marie Curie Paris 6; Paris, France ; Molecular Pathology Group; AstraZeneca; Alderley Park; Cheshire, UK.

Abstract

Understanding the spontaneous immune response of cancer patients is critical for the design of efficient anticancer immunotherapies. The power of integrative tumor immunology approaches allowed for a comprehensive view of the immune system evolution in the course of tumor progression and recurrence. We have demonstrated that tumor-infiltrating immune cells are spatiotemporally regulated, a finding that has profound implications for the development of efficient anticancer immunotherapies.

KEYWORDS:

bioinformatics; cancer; immune landscape; immunoscore; prognosis

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