Send to

Choose Destination
Stroke Res Treat. 2014;2014:348147. doi: 10.1155/2014/348147. Epub 2014 Apr 1.

Endovascular and Surgical Treatment of Unruptured MCA Aneurysms: Meta-Analysis and Review of the Literature.

Author information

University of Florida, Department of Neurosurgery, P.O. Box 100265, Gainesville, FL 32610-0265, USA.
University of Florida, Department of Neurosurgery, P.O. Box 100265, Gainesville, FL 32610-0265, USA ; Assiut University, Department of Radiology, Assiut 71515, Egypt.
University of Florida, College of Medicine, Gainesville, FL 32603, USA.
Division of Interventional Neuroradiology, Abbott Northwestern Hospital, Minneapolis, MN 55407, USA.



The best treatment for unruptured middle cerebral artery (MCA) aneurysms is unclear. We perform a meta-analysis of recent publications to evaluate the results of unruptured MCA aneurysms treated with surgical clipping and endovascular coiling.


A PubMed search for articles published between January 2004 and November 2013 was performed. The R statistical software package was used to create a random effects model for each desired incidence rate. Cochran's Q test was used to evaluate possible heterogeneity among the rates observed in each study.


A total of 1891 unruptured MCA aneurysms, 1052 clipped and 839 coiled, were included for analysis. The complete occlusion rate at 6-9 months mean follow-up was 95.5% in the clipped group and 67.8% in the coiled group (P < 0.05). The periprocedural thromboembolism rate in the clipping group was 1.8% compared with 10.7% in the aneurysms treated by coiling (P < 0.05). The recanalization rate was 0% for clipping and 14.3% for coiling (P = 0.05). Modified Rankin scores of 0-2 were obtained in 98.9% of clipped patients compared to 95.5% of coiled (NS).


This review weakly supports clipping as the preferred treatment of unruptured MCA aneurysms. Clinical outcomes did not differ significantly between the two groups.

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center