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Ann Burns Fire Disasters. 2013 Dec 31;26(4):189-92.

Coexistence of Extended Spectrum Beta-Lactamases, AmpC Beta-Lactamases and Metallo-Beta-Lactamases in Acinetobacter baumannii from burns patients: a report from a tertiary care centre of India.

Author information

1
Government Medical College Hospital, Sector 32, Chandigarh, India Department of Microbiology.
2
Department of Surgery.

Abstract

in English, French

Multidrug-resistant Acinetobacter baumanii is a major pathogen encountered in pyogenic infections, especially from burns patients in hospital settings. Often there is also coexistence of multiple beta-lactamase enzymes responsible for beta-lactam resistance in a single isolate, which further complicates treatment options. We conducted a study on burn wound pus samples obtained from the burns unit of our hospital. Phenotypic tests were used to determine the Extended Spectrum Beta-Lactamase, AmpC Beta-Lactamase and Metallo-Beta-Lactamase producing status of the isolates. Almost half of the samples from the burn wounds yielded Acinetobacter baumanii as the predominant pathogen (54.05%). Coexistence of the three resistance mechanisms was seen in 25 of the 100 (25%) isolates of Acinetobacter baumanii. This study emphasizes the need for the detection of isolates that produce these enzymes to avoid therapeutic failures and nosocomial outbreaks.

KEYWORDS:

Acinetobacter baumanii; AmpC Beta-Lactamase; Extended Spectrum Beta-Lactamase; Metallo-Beta-Lactamase

PMID:
24799848
PMCID:
PMC3978590
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