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Sci Rep. 2014 May 6;4:4693. doi: 10.1038/srep04693.

Bin/Amphiphysin/Rvs (BAR) family members bend membranes in cells.

Author information

1
Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
2
Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, 113-0033, Japan.
3
Integrated Imaging Center, Department of Biology, Johns Hopkins University, Baltimore, MD 21218.
4
1] Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 [2] PRESTO Investigator, JST, 4-1-8 Honcho Kawaguchi, Saitama 332-0012, Japan.

Abstract

We provide direct evidence that Bin/Amphiphysin/Rvs (BAR) family members bend the steady state membrane architecture of organelles in intact cells. In response to inducible BAR molecular actuators, organelles exhibit distinct changes to the orientation and degree of their membrane curvature. This rapidly inducible system may offer a mechanism by which to better understand the structure-function relationship of intracellular organelles.

PMID:
24796975
PMCID:
PMC4894391
DOI:
10.1038/srep04693
[Indexed for MEDLINE]
Free PMC Article

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