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Gene. 1989 Oct 15;82(1):63-4.

Catalysis by the RNA subunit of RNase P--a minireview.

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Department of Biology, Yale University, New Haven, CT 06520.


RNase P, an enzyme that contains both RNA and protein components, cleaves tRNA precursors to generate mature 5' termini. The catalytic activity of RNase P resides in the RNA component, with the protein cofactor affecting the rate of the cleavage reaction. The reaction is also influenced by the nature of the tRNA substrate.

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