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Toxicol Res. 2014 Mar;30(1):49-54. doi: 10.5487/TR.2014.30.1.049.

Hepatoprotective effect of aged black garlic extract in rodents.

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Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Novarex Co., Ltd., Ochang, Cheongwon, Chungbuk, Korea.
Namhaegun Blackgarlic Co., Ltd., 176-40, Seolcheon-ro, Seolcheon-myeon, Namhae-gun, Gyeongsangnam-do, Korea.


In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.


Aged black garlic; Carbon tetrachloride; D-galactosamine; Liver injury; Non-alcoholic fatty liver disease

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