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Toxicol Res. 2014 Mar;30(1):49-54. doi: 10.5487/TR.2014.30.1.049.

Hepatoprotective effect of aged black garlic extract in rodents.

Author information

1
Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Ochang, Cheongwon, Chungbuk, Korea.
2
College of Pharmacy, Chungbuk National University, Cheongju, Korea.
3
Novarex Co., Ltd., Ochang, Cheongwon, Chungbuk, Korea.
4
Namhaegun Blackgarlic Co., Ltd., 176-40, Seolcheon-ro, Seolcheon-myeon, Namhae-gun, Gyeongsangnam-do, Korea.

Abstract

In this study, we investigated the hepatoprotective effects of aged black garlic (ABG) in rodent models of liver injury. ABG inhibited carbon tetrachloride-induced elevation of aspartate transaminase (AST) and alanine transaminase (ALT), which are markers of hepatocellular damage, in SD rats. D-galactosamineinduced hepatocellular damage was also suppressed by ABG treatment. However, ABG does not affect the elevation of alkaline phosphatase (ALP), a marker of hepatobilliary damage, in rats treated with carbon tetrachloride or D-galactosamine. We also examined the effect of ABG on high-fat diet (HFD)-induced fatty liver and subsequent liver damage. ABG had no significant effect on body weight increase and plasma lipid profile in HFD-fed mice. However, HFD-induced increase in AST and ALT, but not ALP, was significantly suppressed by ABG treatment. These results demonstrate that ABG has hepatoprotective effects and suggest that ABG supplementation might be a good adjuvant therapy for the management of liver injury.

KEYWORDS:

Aged black garlic; Carbon tetrachloride; D-galactosamine; Liver injury; Non-alcoholic fatty liver disease

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