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J Infect Dis. 2014 Nov 15;210(10):1595-9. doi: 10.1093/infdis/jiu250. Epub 2014 May 1.

Identification of a novel polyomavirus in a pancreatic transplant recipient with retinal blindness and vasculitic myopathy.

Author information

1
Center for Infection and Immunity.
2
Division of Infectious Diseases, Columbia University, New York, New York.
3
Pathology and Laboratory Medicine, Rutgers University, New Brunswick, New Jersey.
4
Department of Biological Sciences, University of Pittsburgh, Pennsylvania.
5
Pathology and Cell Biology, Columbia University, New York, New York.

Abstract

BACKGROUND:

A 33 year-old pancreatic transplant recipient developed weakness, retinal blindness, and necrotic plaques on her face, scalp, and hands.

METHODS:

A muscle biopsy was analyzed by light and electron microscopy and high-throughput nucleic acid sequencing.

RESULTS:

The biopsy revealed microthrombosis and viral particles in swollen endothelial cell nuclei. High-throughput sequencing of nucleic acid revealed a novel polyomavirus. In situ hybridization confirmed the presence of the polyomavirus in endothelial cells at sites of myositis and cutaneous necrosis.

CONCLUSIONS:

New Jersey polyomavirus (NJPyV-2013) is a novel polyomavirus that may have tropism for vascular endothelial cells.

KEYWORDS:

immunosuppression; myositis; polyomavirus; transplantation; vasculitis; virus discovery

PMID:
24795478
PMCID:
PMC4334791
DOI:
10.1093/infdis/jiu250
[Indexed for MEDLINE]
Free PMC Article

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