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Curr Opin Neurobiol. 2014 Aug;27:199-207. doi: 10.1016/j.conb.2014.04.001. Epub 2014 May 4.

Axon regeneration in C. elegans.

Author information

1
Department of Genetics and Program in Cellular Neuroscience, Neurodegeneration, and Repair, Yale University, New Haven, CT 06520, United States. Electronic address: marc.hammarlund@yale.edu.
2
Section of Neurobiology and Department of Cellular and Molecular Medicine, Howard Hughes Medical Institute, University of California, San Diego, CA 92093, United States. Electronic address: yijin@ucsd.edu.

Abstract

Single axon transection by laser surgery has made Caenorhabditis elegans a new model for axon regeneration. Multiple conserved molecular signaling modules have been discovered through powerful genetic screening. In vivo imaging with single cell and axon resolution has revealed unprecedented cellular dynamics in regenerating axons. Information from C. elegans has greatly expanded our knowledge of the molecular and cellular mechanisms of axon regeneration.

PMID:
24794753
PMCID:
PMC4122601
DOI:
10.1016/j.conb.2014.04.001
[Indexed for MEDLINE]
Free PMC Article

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