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J Neuroimmunol. 2014 Jun 15;271(1-2):49-52. doi: 10.1016/j.jneuroim.2014.04.006. Epub 2014 Apr 16.

No association of IFI16 (interferon-inducible protein 16) variants with susceptibility to multiple sclerosis.

Author information

1
Don C. Gnocchi Foundation ONLUS, IRCCS, 20100 Milan, Italy.
2
Don C. Gnocchi Foundation ONLUS, IRCCS, 20100 Milan, Italy; Department of Physiopathology and Transplantation, University of Milan, 20090 Milano, Italy.
3
Scientific Institute IRCCS E. Medea, 23842 Bosisio Parini, LC, Italy.
4
Department of Neurology-Neuroimmunology, Centre d' Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d' Hebron (HUVH), Barcelona, Spain.
5
Dino Ferrari Centre, Department of Physiopathology and Transplantation, University of Milan, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, 20122 Milan, Italy.
6
Dipartimento di Biotecnologie Mediche e Medicina Traslazionale, Università degli Studi di Milano, Milano, Italy.
7
Scientific Institute IRCCS E. Medea, 23842 Bosisio Parini, LC, Italy; Dino Ferrari Centre, Department of Physiopathology and Transplantation, University of Milan, Fondazione Ca' Granda IRCCS Ospedale Maggiore Policlinico, 20122 Milan, Italy.
8
Scientific Institute IRCCS E. Medea, 23842 Bosisio Parini, LC, Italy. Electronic address: manuela.sironi@bp.lnf.it.

Abstract

IFI16 encodes a nucleic acid-sensor which detects latent EBV and triggers inflammasome activation. We analysed IFI16 variants in two multiple sclerosis (MS) case-control cohorts from Italy and Spain; results were combined with a previous study. A risk variant for celiac disease/rheumatoid arthritis, a polymorphic exon 7 duplication, and a copy number variant (CNV) in the 5' region were genotyped. No significant association was detected, although heterogeneity was noted for the 5' CNV in the Italian plus GeneMSA cohorts and the Spanish sample. Thus, IFI16 variants do not contribute to MS susceptibility, although some heterogeneity may exist for the 5' CNV.

KEYWORDS:

EBV infection; Genetic susceptibility; IFI16 (interferon-inducible protein 16); Multiple sclerosis

PMID:
24794504
DOI:
10.1016/j.jneuroim.2014.04.006
[Indexed for MEDLINE]
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