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J Zhejiang Univ Sci B. 2014 May;15(5):429-37. doi: 10.1631/jzus.B1400076.

The polyadenylation code: a unified model for the regulation of mRNA alternative polyadenylation.

Author information

1
Department of Microbiology and Molecular Genetics, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.

Abstract

The majority of eukaryotic genes produce multiple mRNA isoforms with distinct 3' ends through a process called mRNA alternative polyadenylation (APA). Recent studies have demonstrated that APA is dynamically regulated during development and in response to environmental stimuli. A number of mechanisms have been described for APA regulation. In this review, we attempt to integrate all the known mechanisms into a unified model. This model not only explains most of previous results, but also provides testable predictions that will improve our understanding of the mechanistic details of APA regulation. Finally, we briefly discuss the known and putative functions of APA regulation.

KEYWORDS:

Alternative polyadenylation (APA); Polyadenylation site (PAS); mRNA

PMID:
24793760
PMCID:
PMC4076599
DOI:
10.1631/jzus.B1400076
[Indexed for MEDLINE]
Free PMC Article

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