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Int J Gynaecol Obstet. 2014 Jul;126(1):28-32. doi: 10.1016/j.ijgo.2014.01.020. Epub 2014 Apr 3.

Distribution of various types of low-risk human papillomavirus according to cervical cytology and histology in northern Chinese women.

Author information

1
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China.
2
Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, China. Electronic address: zhangsl0909@163.com.

Abstract

OBJECTIVE:

To describe the distribution of specific types of low-risk (LR) human papillomavirus (HPV) among a general population of northern Chinese women.

METHODS:

Between 2007 and 2012, 118 096 women were tested with the HPV Geno-Array Test Kit (HybriBio) at China Medical University's Shengjing Affiliated Hospital, Shenyang, China. Among these women, 80 418 underwent cervical cytology and colposcopic examination, and 30 961 of these had a cervical biopsy. The prevalence of HPV infection among the women was analyzed according to age, and cytologic and histologic findings.

RESULTS:

CP8304 was the most common type of LR-HPV overall, and was most prevalent in the youngest age group. The overall prevalence of LR-HPV (averaged across all types) was 1.7% in women with normal cytology, 8.8% in those with atypical squamous cells of undetermined significance (ASCUS), 8.0% in those with low-grade squamous intraepithelial lesions (LSIL), and 5.8% in those with high-grade squamous intraepithelial lesions (HSIL). LR-HPV alone, without any high-risk (HR)-HPV, was most common among women with ASCUS and cervical intraepithelial neoplasia (CIN) not otherwise specified (CINNOS) together. Co-infections of LR-HPV and HR-HPV were most common among women with LSIL and CIN1.

CONCLUSION:

These data will facilitate modeling of the cost-effectiveness of a prophylactic LR-HPV vaccination in China.

KEYWORDS:

CIN not otherwise specified; Cervical cancer; Cervical intraepithelial neoplasia (CIN); High-risk human papillomavirus; Low-risk human papillomavirus

PMID:
24792409
DOI:
10.1016/j.ijgo.2014.01.020
[Indexed for MEDLINE]
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