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Neurosci Lett. 2014 Jun 20;572:58-62. doi: 10.1016/j.neulet.2014.04.034. Epub 2014 May 2.

Spicatoside A enhances memory consolidation through the brain-derived neurotrophic factor in mice.

Author information

1
Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea.
2
Department of Food and Nutrition, Andong National University, Andong 760-749, Republic of Korea.
3
Department of Food and Nutrition, Andong National University, Andong 760-749, Republic of Korea. Electronic address: sonkh@andong.ac.kr.
4
Department of Life and Nanopharmaceutical Science, Kyung Hee University, Seoul 130-701, Republic of Korea; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea; Kyung Hee East-West Pharmaceutical Research Institute, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea. Electronic address: jhryu63@khu.ac.kr.

Abstract

Brain-derived neurotrophic factor (BDNF) plays a pivotal role in memory consolidation. Previously, we found that the increased mature BDNF (mBDNF) levels in the hippocampal region at a specific time window after the acquisition trial are required for memory consolidation. In the present study, we investigated whether spicatoside A enhances memory consolidation, and whether its effects on memory consolidation are related to hippocampal mBDNF levels. Spicatoside A (2.5, 5, 10 or 20mg/kg) enhanced memory consolidation in a dose-dependent manner, and enhanced memory consolidation was also observed when spicatoside A was administered 1h after the acquisition trial. Concurrently, when spicatoside A was administered immediately or 1h after the acquisition trial, hippocampal mBDNF levels were similar or significantly increased at 9h after the acquisition trial compared to levels at 6h. These results suggest that increased mBDNF levels in the hippocampal region at 9h after the acquisition trial might play a pivotal role in memory consolidation and that spicatoside A might enhance memory consolidation by increasing hippocampal mBDNF levels.

KEYWORDS:

BDNF; Hippocampus; Memory consolidation; Spicatoside A

PMID:
24792393
DOI:
10.1016/j.neulet.2014.04.034
[Indexed for MEDLINE]

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