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Am J Geriatr Psychiatry. 2014 Oct;22(10):997-1006.e5. doi: 10.1016/j.jagp.2014.03.009. Epub 2014 Mar 26.

Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.

Author information

1
Sam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA.
2
Scripps Translational Science Institute, Scripps Genomic Medicine, Scripps Health, La Jolla, CA.
3
Sam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA; Veterans Affairs San Diego Healthcare System, San Diego, CA.
4
Department of Family and Preventive Medicine, University of California, San Diego, CA.
5
Department of Surgery, Division of Urologic Oncology, University of California, San Diego, CA.
6
J. Craig Venter Institute, La Jolla, CA.
7
Sam and Rose Stein Institute for Research on Aging, and Department of Psychiatry, University of California, San Diego, CA. Electronic address: djeste@ucsd.edu.

Abstract

OBJECTIVE:

Optimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults.

DESIGN:

Candidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT).

PARTICIPANTS:

426 women from WHI older than age 50 years, and 509 men older than age 55 years (age 50 years for African American men) from SELECT.

MEASUREMENTS:

65 candidate gene SNPs that were judged by consensus, based on a literature review, as being related to predisposition to optimism and resilience, and 31 ancestry informative marker SNPs, genotyped from blood-based DNA samples and self-report scales for trait optimism, resilience, and depressive symptoms.

RESULTS:

Using a Bonferroni threshold for significant association (p = 0.00089), there were no significant associations for individual SNPs with optimism or resilience in single-locus analyses. Exploratory multi-locus polygenic analyses with p <0.05 showed an association of optimism with SNPs in MAOA, IL10, and FGG genes, and an association of resilience with a SNP in MAOA gene.

CONCLUSIONS:

Correcting for Type I errors, there were no significant associations of optimism and resilience with specific gene SNPs in single-locus analyses. Positive psychological traits are likely to be genetically complex, with many loci having small effects contributing to phenotypic variation. Our exploratory multi-locus polygenic analyses suggest that larger sample sizes and complementary approaches involving methods such as sequence-based association studies, copy number variation analyses, and pathway-based analyses could be useful for better understanding the genetic basis of these positive psychological traits.

KEYWORDS:

Optimism; aging; depression; genotyping; resilience; single-nucleotide polymorphisms

PMID:
24791650
PMCID:
PMC4163500
DOI:
10.1016/j.jagp.2014.03.009
[Indexed for MEDLINE]
Free PMC Article

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