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Am J Surg. 2014 May;207(5):712-6. doi: 10.1016/j.amjsurg.2013.12.019. Epub 2014 Mar 12.

Predictive utility of cyclo-oxygenase-2 expression by colon and rectal cancer.

Author information

1
Department of Surgery, St Paul's Hospital and University of British Columbia, Room C303, Burrard Building, 1081 Burrard Street, Vancouver, British Columbia, Canada.
2
Department of Medical Genetics, University of British Columbia and Michael Smith Genome Sciences Center, British Columbia Cancer Research Center, Vancouver, British Columbia, Canada.
3
Department of Pathology and Lab Medicine, University of British Columbia, Vancouver, British Columbia, Canada; PhenoPath Laboratories, Seattle, WA, USA.
4
Department of Surgery, St Paul's Hospital and University of British Columbia, Room C303, Burrard Building, 1081 Burrard Street, Vancouver, British Columbia, Canada. Electronic address: smwiseman@providencehealth.bc.ca.

Abstract

BACKGROUND:

Cyclo-oxygenase-2 (COX-2), an inducible enzyme expressed in areas of inflammation, is a target of interest for colorectal cancer therapy. Currently, the predictive significance of COX-2 in colorectal cancer remains unclear.

METHODS:

Tissue microarrays were constructed using 118 colon cancer and 85 rectal cancer specimens; 44 synchronous metastatic colon cancer and 22 rectal cancer lymph nodes were also evaluated. COX-2 expression was assessed by immunohistochemistry. Univariate analysis was used to determine the predictive significance of clinicopathologic variables. Overall survival, disease-specific survival, and disease-free survival were the main outcomes examined.

RESULTS:

COX-2 was found to be expressed in 93% of colon cancers and 87% of rectal cancers. Decreased COX-2 expression was related to decreased disease-specific survival (P = .016) and decreased disease-free survival (P = .019) in the rectal cancer cohort but not in the colon cancer cohort.

CONCLUSIONS:

COX-2 expression has predictive utility for management of rectal but not colon cancer.

KEYWORDS:

Colon cancer; Colorectal cancer; Cyclo-oxygenase-2; Immunohistochemistry; Rectal cancer

PMID:
24791632
DOI:
10.1016/j.amjsurg.2013.12.019
[Indexed for MEDLINE]
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