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Oncoimmunology. 2014 Jan 1;3(1):e27763. Epub 2014 Jan 10.

Toll-like receptor genetic variants and colorectal cancer.

Author information

  • 1Interfaculty Institute for Cell Biology; Department of Immunology; University of Tübingen; Tübingen, Germany.
  • 2Division of Molecular Genetic Epidemiology; German Cancer Research Center (DKFZ); Heidelberg, Germany ; Center for Primary Health Care Research; Clinical Research Center; Lund University; Malmö, Sweden.

Abstract

Single-nucleotide polymorphisms in Toll-like receptor 5 (TLR5), encoding a sensor for flagellin, have been shown to influence cytokine responses to intestinal bacteria and to be associated with significant alterations in the survival of colorectal carcinoma (CRC) patients. These findings point to a link between TLRs and CRC that may have both therapeutic and prognostic/predictive implications.

KEYWORDS:

Toll-like receptors; biomarker; colorectal cancer; flagellin; single-nucleotide polymorphism

PMID:
24790794
PMCID:
PMC4004619
DOI:
10.4161/onci.27763
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