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J Contemp Brachytherapy. 2014 Mar;6(1):91-8. doi: 10.5114/jcb.2014.42026. Epub 2014 Apr 3.

High-dose-rate brachytherapy as monotherapy for prostate cancer: technique, rationale and perspective.

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Department of Radiation Oncology, Osaka University Graduate School of Medicine, Osaka, Japan.
Department of Radiology, Osaka Medical College, Osaka, Japan.
Department of Radiation Oncology, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan.


High-dose-rate (HDR) brachytherapy as monotherapy is a comparatively new brachytherapy procedure for prostate cancer. Although clinical results are not yet mature enough, it is a highly promising approach in terms of potential benefits for both radiation physics and radiobiology. In this article, we describe our technique for monotherapeutic HDR prostate brachytherapy, as well as the rationale and theoretical background, with educational intent.


high-dose-rate (HDR) brachytherapy; hypofractionation; monotherapy; prostate cancer; radiotherapy

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