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Circulation. 2014 Jul 1;130(1):18-26. doi: 10.1161/CIRCULATIONAHA.113.006921. Epub 2014 Apr 30.

Extravirgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención con Dieta Mediterránea) trial.

Collaborators (234)

Estruch R, Corella D, Covas MI, Ros E, Salas-Salvadó J, Martínez-González MA, Aldamiz M, Alonso A, Berjón J, Forga L, Gállego J, Layana A, Larrauri A, Portu J, Timiraus J, Serrano-Martínez M, Ros E, Martínez-González MA, Covas MI, Pérez-Heras A, Salas-Salvadó J, Serra M, Pi-Sunyer X, González CA, Hu FB, Sabaté J, Ruiz-Canela M, Sánchez-Tainta A, Sanjulián B, Diez--Espino J, Extremera-Urabayen V, García-Arellano A, Zazpe I, Basterra-Gortari FJ, Goñi JM, Razquin C, Serrano-Martínez M, Bes-Rastrollo M, Gea A, Martínez-Lapiscina EH, Nuñez-Córdoba JM, Arroyo-Azpa C, García-Pérez L, Villanueva-Tellería J, Cortes-Ugalde F, Sagredo-Arce T, García de la Noceda-Montoy MD, Vigata-López MD, Arceiz-Campo MT, Urtasun-Samper A, Gueto-Rubio MV, Churio-Beraza B, Bulló M, González R, Molina C, Márquez F, Babio N, Sorli M, García Roselló J, Guasch-Ferré M, Diaz-López A, Martin AF, Tort R, Isach A, Costa B, Cabré JJ, Fernández-Ballart J, Ibarrola-Jurado N, Alegret C, Martínez P, Millán S, Piñol JL, Basora T, Hernández JM, Serra M, Pérez-Heras A, Viñas C, Casas R, de Santamaría L, Romero S, Sacanella E, Chiva G, Valderas P, Arranz S, Baena JM, García M, Oller M, Amat J, Duaso I, García Y, Iglesias C, Simón C, Quinzavos L, Parra L, Liroz M, Benavent J, Clos J, Pla I, Amorós M, Bonet MT, Martin MT, Sanchez MS, Altirriba J, Manzano E, Altés A, Cofán M, Valls-Pedret C, Sala-Vila A, Doménech M, Gilabert R, Bargalló N, Tello S, Vila J, Schröder H, De la Torre R, Muñoz-Aguayo D, Elosúa R, Marrugat J, Ferrer M, Carrasco P, Osma R, Guillém-Saiz P, Portolés O, Pascual V, Riera C, Valderrama J, Serrano A, Lázaro E, Sanmartín A, Girbés A, Santamarí V, Sánchez C, Plá Z, Sánchez E, Ortega-Azorín C, González JI, Saiz C, Coltell O, Asensio EM, Salaverría I, del Hierro T, Algorta J, Francisco S, Alonso A, San Vicente J, Sanz E, Felipe I, Alonso Gómez A, Loma-Osorio A, Gomez-Gracia E, Benítez Pont R, Bianchi Alba M, Wärnberg J, Gómez-Huelgas R, Martínez-González J, Velasco García V, de Diego Salas J, Baca Osorio A, Zarzosa JG, Sánchez Luque JJ, Vargas López E, Jurado Ruiz E, Romero M, García García M, García-Valdueza M, Moñino M, Proenza A, Prieto R, Frontera G, Ginard M, Fiol F, Jover A, García J, Leal M, Martínez E, Santos JM, Ortega-Calvo M, Roman P, García FJ, Iglesias P, Corchado Y, Mayoral E, Lama C, López-Sabater MC, Castellote-Bargallo AI, Medina-Remón A, Tresserra-Rimbau A, Álvarez-Pérez J, DíazBenítez E, Bautista-Castaño I, Maldonado-Díaz I, Sánchez-Villegas A, Castro I, Henríquez P, Ruano C, Ortiz AP, Sarmiendo de la Fe F, Simón-García C, Falcón-Sanabria I, Macías-Gutiérrez B, Santana-Santana AJ, de la Cruz E, Galera A, Soler Y, Trias F, Sarasa I, Padres E, Figueras R, Solanich X, Pujol R, Corbella E, Cabezas C, Vinyoles E, Rovira MA, García L, Flores G, Verdú JM, Baby P, Ramos A, Mengual L, Roura P, Yuste MC, Guarner A, Rovira A, Santamaria MI, Mata M, de Juan C, Brau A, Martinez JA, Marti A, Mitjavila MT, Portillo MP, Sáez G, Tur J.

Abstract

BACKGROUND:

The PREDIMED (Prevención con Dieta Mediterránea) randomized primary prevention trial showed that a Mediterranean diet enriched with either extravirgin olive oil or mixed nuts reduces the incidence of stroke, myocardial infarction, and cardiovascular mortality. We assessed the effect of these diets on the incidence of atrial fibrillation in the PREDIMED trial.

METHODS AND RESULTS:

Participants were randomly assigned to 1 of 3 diets: Mediterranean diet supplemented with extravirgin olive oil, Mediterranean diet supplemented with mixed nuts, or advice to follow a low-fat diet (control group). Incident atrial fibrillation was adjudicated during follow-up by an events committee blinded to dietary group allocation. Among 6705 participants without prevalent atrial fibrillation at randomization, we observed 72 new cases of atrial fibrillation in the Mediterranean diet with extravirgin olive oil group, 82 in the Mediterranean diet with mixed nuts group, and 92 in the control group after median follow-up of 4.7 years. The Mediterranean diet with extravirgin olive oil significantly reduced the risk of atrial fibrillation (hazard ratio, 0.62; 95% confidence interval, 0.45-0.85 compared with the control group). No effect was found for the Mediterranean diet with nuts (hazard ratio, 0.89; 95% confidence interval, 0.65-1.20).

CONCLUSIONS:

In the absence of proven interventions for the primary prevention of atrial fibrillation, this post hoc analysis of the PREDIMED trial suggests that extravirgin olive oil in the context of a Mediterranean dietary pattern may reduce the risk of atrial fibrillation.

CLINICAL TRIAL REGISTRATION URL:

http://www.controlled-trials.com. Unique identifier: ISRCTN35739639.

KEYWORDS:

antioxidants; arrhythmia; atrial fibrillation; diet; epidemiology; fatty acids, monounsaturated; inflammation

[PubMed - indexed for MEDLINE]
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