Send to

Choose Destination
J Bioenerg Biomembr. 1989 Aug;21(4):507-18.

Studies on the interaction between mitochondria and the cytoskeleton.

Author information

Department of Biochemistry, University of Stockholm, Sweden.


Mitochondrial movements and morphology are regulated through interactions with the cytoskeletal system, in particular the microtubules. An interaction between the microtubule-associated proteins (MAPs) and the outer surface of rat brain mitochondria has been demonstrated in vitro and in situ. One of the MAPs, MAP2, binds to specific high-affinity sites on the outer membrane. Upon binding, MAP2 is released from microtubules, and it induces a physical alteration in the outer membrane which is characterized by a tighter association of porin with the membrane. It is concluded that MAP2 either binds to porin or to a domain of the outer membrane which alters the membrane environment of porin. The possibility is raised that this domain participates in mitochondrial mobility in situ.

[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center