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J Bioenerg Biomembr. 1989 Aug;21(4):507-18.

Studies on the interaction between mitochondria and the cytoskeleton.

Author information

1
Department of Biochemistry, University of Stockholm, Sweden.

Abstract

Mitochondrial movements and morphology are regulated through interactions with the cytoskeletal system, in particular the microtubules. An interaction between the microtubule-associated proteins (MAPs) and the outer surface of rat brain mitochondria has been demonstrated in vitro and in situ. One of the MAPs, MAP2, binds to specific high-affinity sites on the outer membrane. Upon binding, MAP2 is released from microtubules, and it induces a physical alteration in the outer membrane which is characterized by a tighter association of porin with the membrane. It is concluded that MAP2 either binds to porin or to a domain of the outer membrane which alters the membrane environment of porin. The possibility is raised that this domain participates in mitochondrial mobility in situ.

PMID:
2478536
DOI:
10.1007/bf00762522
[Indexed for MEDLINE]

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