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Biomed Res Int. 2014;2014:404680. doi: 10.1155/2014/404680. Epub 2014 Mar 25.

Effect of antioxidants supplementation on aging and longevity.

Author information

1
Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza Street 4, 35-601 Rzeszów, Poland.
2
Department of Biochemistry and Cell Biology, University of Rzeszów, Zelwerowicza Street 4, 35-601 Rzeszów, Poland ; Department of Molecular Biophysics, University of Łódź, Pomorska 141/143, 90-236 Łódź, Poland.

Abstract

If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by administration of exogenous antioxidants. This paper reviews data on model organisms concerning the effects of exogenous antioxidants (antioxidant vitamins, lipoic acid, coenzyme Q, melatonin, resveratrol, curcumin, other polyphenols, and synthetic antioxidants including antioxidant nanoparticles) on the lifespan of model organisms. Mechanisms of effects of antioxidants, often due to indirect antioxidant action or to action not related to the antioxidant properties of the compounds administered, are discussed. The legitimacy of antioxidant supplementation in human is considered.

PMID:
24783202
PMCID:
PMC3982418
DOI:
10.1155/2014/404680
[Indexed for MEDLINE]
Free PMC Article

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