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Cell. 1989 Oct 20;59(2):247-55.

Antigen recognition in autoimmune encephalomyelitis and the potential for peptide-mediated immunotherapy.

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Department of Microbiology and Immunology, Stanford University School of Medicine, California 94305.


Peptide binding and lymph node T cell activation studies have been used to characterize T cell recognition of an encephalitogenic T cell autoantigen from myelin basic protein in (PL/J x SJL)F1 mice. Amino acids that determine interactions with either the restriction element of the major histocompatibility complex (MHC) or the encephalitogenic T cell receptor are defined. This information enables the design of peptides that bind MHC yet do not cross-react with the autoantigen. A peptide analog of the encephalitogenic epitope is shown to be "heteroclitic" for MHC binding and activation of encephalitogenic T cells in vitro. This analog is not immunogenic for encephalitogenic T cells in vivo and is shown to inhibit disease that is induced by the autoantigen itself.

[Indexed for MEDLINE]

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