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Sci Rep. 2014 Apr 30;4:4862. doi: 10.1038/srep04862.

Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement.

Author information

1
1] Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan [2] Research Center for Inflammation and Regenerative Medicine, Faculty of Life and Medical Sciences, Doshisha University, Kyoto, Japan.
2
Division of Medicinal Safety Science, National Institute of Health Sciences, Tokyo, Japan.
3
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
4
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
5
Molecular Diagnostics Division, Wakunaga Pharmaceutical Co., Hiroshima, Japan.
6
Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, Kanagawa, Japan.
7
Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan.
8
National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan.
9
Department of Neurology, Faculty of Medicine, Kochi University, Kochi, Japan.
10
Molecular Epidemiology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
11
Department of Dermatology, International University of Health and Welfare (IUHW) Atami Hospital, Shizuoka, Japan.

Abstract

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs (NSAIDs) and multi-ingredient cold medications are reported to be important inciting drugs. We used two sample sets of Japanese patients to investigate the association between HLA genotypes and cold medicine-related SJS/TEN (CM-SJS/TEN), including acetaminophen-related SJS/TEN (AR-SJS/TEN) with severe mucosal involvement such as severe ocular surface complications (SOC). HLA-A*02:06 was strongly associated with CM-SJS/TEN with SOC and AR-SJS/TEN with SOC. HLA-B*44:03 was also detected as an independent risk allele for CM-, including AR-SJS/TEN with SOC. Analyses using data obtained from CM-SJS/TEN patients without SOC and patients with CM-unrelated SJS/TEN with SOC suggested that these two susceptibility alleles are involved in the development of only CM-SJS/TEN with SOC patients.

PMID:
24781922
PMCID:
PMC5381277
DOI:
10.1038/srep04862
[Indexed for MEDLINE]
Free PMC Article
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