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Immunol Today. 1989 Aug;10(8):258-61.

Inflammatory and immunomodulatory roles of TGF-beta.

Abstract

Transforming growth factors (TGFs) are small polypeptides that were initially defined by their ability to induce transformation of non-neoplastic cells in culture. However, it has become increasingly clear that TGFs are not restricted in function to promoting cell growth. One type of transforming growth factor, TGF-beta, is a multifunctional molecule which has unique and potent effects on many target cells and tissues. In this article, Sharon Wahl, Nancy McCartney-Francis and Stephan Mergenhagen focus on the evolving role of TGF-beta in regulating inflammation, immune responses and tissue repair.

PMID:
2478145
DOI:
10.1016/0167-5699(89)90136-9
[Indexed for MEDLINE]

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