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Mult Scler. 2014 Dec;20(14):1866-71. doi: 10.1177/1352458514531084. Epub 2014 Apr 29.

Identical lesion morphology in primary progressive and relapsing-remitting MS--an ultrahigh field MRI study.

Author information

1
NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany.
2
NeuroCure Clinical Research Center/Clinical and Experimental MS Research Center, Charité - Universitaetsmedizin Berlin, Berlin, Germany.
3
Clinical and Experimental MS Research Center/Charité - Universitaetsmedizin Berlin, Berlin, Germany.
4
Berlin Ultrahigh Field Facility (BUFF)/Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany.
5
NeuroCure Clinical Research Center/Clinical and Experimental MS Research Center/Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany friedemann.paul@charite.de.
6
NeuroCure Clinical Research Center, Charité - Universitaetsmedizin Berlin, Germany/Asklepios Fachklinikum Teupitz, Germany.
7
NeuroCure Clinical Research Center/BUFF, Max Delbrueck Center for Molecular Medicine, Berlin, Germany/Experimental and Clinical Research Center, Charité - Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin/Institute of Neuroradiology, University Medicine Goettingen, Germany.

Abstract

Potential differences between primary progressive (PP) and relapsing-remitting (RR) multiple sclerosis (MS) have been controversially discussed. In this study, we compared lesion morphology and distribution in patients with PPMS and RRMS (nine in each group) using 7 T MRI. We found that gray and white matter lesions in PPMS and RRMS patients did not differ in their respective morphological characteristics (e.g., perivascular p = 0.863, hypointense rim p = 0.796, cortical lesion count p = 0.436). Although limited by a small sample size, our study results suggest that PPMS and RRMS, despite differences in disease course and clinical characteristics, exhibit identical lesion morphology under ultrahigh field MRI.

KEYWORDS:

7 T MRI; MRI; PPMS; RRMS; primary progressive multiple sclerosis; relapsing–remitting multiple sclerosis; ultrahigh field MRI

PMID:
24781284
DOI:
10.1177/1352458514531084
[Indexed for MEDLINE]

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