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Parkinsonism Relat Disord. 2014 Jul;20(7):708-15. doi: 10.1016/j.parkreldis.2014.03.020. Epub 2014 Apr 1.

Systematic review of factors associated with depression and anxiety disorders among older adults with Parkinson's disease.

Author information

1
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
2
Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: jgallo@jhsph.edu.
3
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Abstract

Depression and anxiety disorders have a substantial impact on the quality of life, the functioning and mortality of older adults with Parkinson's disease (PD). The purpose of this systematic review was to examine the factors associated with the prevalence of depression and anxiety disorders among individuals with PD aged 60 years and older. Following a literature search in PubMed, PsycINFO, CINAHL, and EMBASE, 5 articles met the inclusion criteria (adults aged 60 years and older, individuals with PD, and with depression and anxiety disorders, and English-language peer reviewed articles) and were included in this review. These studies were conducted in the U.S (n = 3), in Italy (n = 1) and the U.K (n = 1). Findings indicated that autonomic symptoms, motor fluctuations, severity and frequency of symptoms, staging of the disease, and PD onset and duration were associated with the prevalence of depression and anxiety disorders among older adults suffering from PD. Despite the limited number of studies included in the review, depression and anxiety disorders are often unrecognized and untreated and the comorbidity greatly exacerbates PD symptoms. The identification of factors associated with the development of depression and anxiety disorders could help in designing preventive interventions that would decrease the risk and burden of depression and anxiety disorders among older adults with PD.

KEYWORDS:

Anxiety disorders; Depression; Factors; Older adults; Parkinson's disease; Systematic review

PMID:
24780824
PMCID:
PMC4648277
DOI:
10.1016/j.parkreldis.2014.03.020
[Indexed for MEDLINE]
Free PMC Article

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