Format

Send to

Choose Destination
Curr Opin Chem Biol. 2014 Apr;19:42-9. doi: 10.1016/j.cbpa.2013.12.013. Epub 2014 Jan 7.

Interfacial metal coordination in engineered protein and peptide assemblies.

Author information

1
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States.
2
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, United States. Electronic address: tezcan@ucsd.edu.

Abstract

Metal ions are frequently found in natural protein-protein interfaces, where they stabilize quaternary or supramolecular protein structures, mediate transient protein-protein interactions, and serve as catalytic centers. Paralleling these natural roles, coordination chemistry of metal ions is being increasingly utilized in creative ways toward engineering and controlling the assembly of functional supramolecular peptide and protein architectures. Here we provide a brief overview of this emerging branch of metalloprotein/peptide engineering and highlight a few select examples from the recent literature that best capture the diversity and future potential of approaches that are being developed.

PMID:
24780278
DOI:
10.1016/j.cbpa.2013.12.013
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center