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Bioorg Med Chem Lett. 2014 Jun 15;24(12):2773-6. doi: 10.1016/j.bmcl.2014.03.099. Epub 2014 Apr 18.

Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata).

Author information

1
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA.
2
Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48201, USA. Electronic address: kzhou@wayne.edu.

Abstract

Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and HPLC purification. These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells.

KEYWORDS:

Acetogenin; Annona muricata; Cytotoxicity; Human prostate cancer; Muricin

PMID:
24780120
DOI:
10.1016/j.bmcl.2014.03.099
[Indexed for MEDLINE]
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