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Gen Comp Endocrinol. 2014 Jun 1;202:1-7. doi: 10.1016/j.ygcen.2014.04.011. Epub 2014 Apr 26.

Trenbolone acetate metabolites promote ovarian growth and development in adult Japanese medaka (Oryzias latipes).

Author information

1
Department of Environmental Sciences, University of California, Riverside, CA 92521, United States. Electronic address: kforsgren@fullerton.edu.
2
Department of Civil and Environmental Engineering, University of Iowa, Iowa City, IA 52242, United States.
3
Department of Environmental Sciences, University of California, Riverside, CA 92521, United States.

Abstract

Trenbolone acetate, a synthetic androgen, has been used as a growth promoter in beef cattle in the US since 1987. While several teleost studies have investigated the masculinization effects of the metabolite 17β-trenbolone, few have focused on the reproductive impacts of all three trenbolone acetate (TBA) metabolites including trendione. Adult female medaka (Oryzias latipes) were exposed to TBA metabolites (10, 100, and 1000ng/L) for 14days (n=3). Histological examination revealed that TBA metabolites (1000ng/L) significantly reduced the percentage of primary ovarian follicles and increased the percentage of vitellogenic follicles compared to control fish. 17α-Trenbolone significantly increased whereas trendione reduced whole body levels of estradiol-17β. Testosterone was significantly reduced by trendione treatment and only the highest dose of 17β-trenbolone and lowest dose of trendione altered 11-ketotestosterone. Additionally, TBA metabolites may be further broken down and/or metabolized or converted by the animal influencing both sex steroid levels and ovarian development.

KEYWORDS:

Aquatic toxicology; Reproduction; Sex steroids; Trenbolone acetate metabolites

PMID:
24780119
DOI:
10.1016/j.ygcen.2014.04.011
[Indexed for MEDLINE]

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