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Radiat Oncol. 2014 Apr 29;9:101. doi: 10.1186/1748-717X-9-101.

Significance of an increase in the Child-Pugh score after radiotherapy in patients with unresectable hepatocellular carcinoma.

Author information

1
Department of Radiation Oncology, Incheon St, Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea. k41645@chol.com.

Abstract

BACKGROUND:

We attempted to analyze the effects of an increase in the Child-Pugh (CP) score on the overall survival of patients with unresectable hepatocellular carcinoma (HCC) after radiotherapy (RT).

METHODS:

From March 2006 to February 2012, 103 patients received RT using the TomoTherapy Hi-Art at Incheon St. Mary's Hospital and Seoul St. Mary's Hospital. The dose per fraction was 1.8-5 Gy, and the total dose was 40-60 Gy (median, 50 Gy). We considered an increase of at least 2 points in the CP score within 3 months after RT to be clinically important radiation-induced hepatic toxicity and analyzed the effects of an increased CP score on overall survival.

RESULTS:

The median follow-up duration was 11.6 months (range, 3.5-85.3 months). The median survival time was 11.6 months. In multivariate analysis, planning target volume and an increase in the CP score after RT were found to be a statistically significant factors (pā€‰=ā€‰0.010 and 0.015, respectively). In a comparison of cases with and without an increase in the CP score, there was an 11.0-month difference in the median survival time (6.9 vs. 17.9 months), and the relative risk of mortality was 1.8.

CONCLUSION:

An increase of at least 2 points in the CP score within 3 months of RT completion is an important on-treatment factor that affects overall survival. To minimize such increases, careful patient selection and a more sophisticated radiation treatment plan are imperative.

PMID:
24779518
PMCID:
PMC4016647
DOI:
10.1186/1748-717X-9-101
[Indexed for MEDLINE]
Free PMC Article

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