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Org Lett. 2014 May 16;16(10):2630-3. doi: 10.1021/ol500792x. Epub 2014 Apr 29.

Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral.

Author information

1
Department of Chemistry and Center for Drug Discovery and Innovation and ┬žDepartment of Global Health, University of South Florida , Tampa, Florida 33620, United States.

Abstract

The isolation and characterization of two new tricyclic sesquiterpenoids, shagenes A (1) and B (2) are presented. These compounds were isolated from an undescribed soft coral collected from the Scotia Arc in the Southern Ocean. One- and two-dimensional NMR spectroscopy and mass spectrometry provided the data necessary to characterize the compounds and their relative stereochemical configurations. Exploration of the bioactivity of shagenes A and B found 1 active against the visceral leishmaniasis causing parasite, Leishmania donovani, with no cytotoxicity against the mammalian host.

PMID:
24779517
PMCID:
PMC4127331
DOI:
10.1021/ol500792x
[Indexed for MEDLINE]
Free PMC Article

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